Reduced glutathione prevents nitric oxide-induced apoptosis in vascular smooth muscle cells
نویسندگان
چکیده
منابع مشابه
Potentiation of nitric oxide-induced apoptosis in p53-/- vascular smooth muscle cells.
The functional role of p53 in nitric oxide (NO)-mediated vascular smooth muscle cell (VSMC) apoptosis remains unknown. In this study, VSMC from p53-/- and p53+/+ murine aortas were exposed to exogenous or endogenous sources of NO. Unexpectedly, p53-/- VSMC were much more sensitive to the proapoptotic effects of NO than were p53+/+ VSMC. Furthermore, this paradox appeared to be specific to NO, b...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
سال: 1997
ISSN: 0167-4889
DOI: 10.1016/s0167-4889(97)00093-1